NA-Semax Amidate Reference Guide

Compound Reference Overview

Field Value
Name NA-Semax Amidate
Reference Code SEMAX
Category Cognitive / Nootropic Peptide
Example Strength 10 mg vial (varies by manufacturer)
Reference Range 200–1200 mcg daily
Frequency Once or twice daily
Key Safety Warning May be stimulating. Avoid evening dosing. Use caution in bipolar disorder or severe anxiety. Not FDA-approved.

Mechanism of Action (Educational)

NA-Semax Amidate is a stabilized synthetic analog of adrenocorticotropic hormone (ACTH 4-10 fragment). It enhances expression of neurotrophic factors including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF).

It also modulates dopaminergic and serotonergic systems, supporting neuroplasticity, attention, and cognitive performance. The amidate modification increases stability compared to non-amidated Semax.

Indications (Literature / Off-Label)

  • Cognitive enhancement
  • Neuroprotection research
  • Post-stroke recovery (Russia)
  • ADHD symptom support

Administration (Literature)

Parameter Details
Route Subcutaneous or intranasal
Frequency Once or twice daily
Injection Sites Subcutaneous: abdomen
Intranasal: divided doses per nostril
Timing Morning or early afternoon (avoid evening use)

Titration Schedule (Literature)

  • Weeks 1–2: 200–500 mcg once daily (AM)
  • Weeks 3+: 500–1000 mcg daily (may split BID)
  • Upper reference range: 1200 mcg daily

Avoid evening dosing due to potential stimulation or insomnia.

Pharmacokinetics (Literature)

  • Rapid CNS activity (minutes to hours)
  • Cognitive effects reported within hours to days
  • Human PK data remain limited outside Russian literature

Reconstitution & Concentration
(Mathematical Illustration Only)

Parameter Value
Diluent Bacteriostatic water (example only)
Reconstitution Volume 2 mL (example)
Resulting Concentration 5 mg/mL (5000 mcg/mL)
Stability Up to 28 days refrigerated (varies by formulation)

Reconstitution Math Example

  • 10 mg ÷ 2 mL = 5 mg/mL
  • 0.1 mL = 500 mcg
  • 0.2 mL = 1000 mcg

Provided strictly for arithmetic reference only.

Mathematical Calculation Tool

The calculator below allows concentration and volume calculations based on vial strength and dilution volume. This tool is provided strictly for mathematical reference.

Peptide Reconstitution Calculator

For Educational & Professional Reference Only

⚠️ This is a mathematical reference tool only. No medical or dosing advice is provided.

Safety & Contraindications (Summary)

Contraindications

  • Pregnancy or breastfeeding
  • Bipolar disorder (risk of mania)
  • Severe anxiety disorders

Drug Interactions

  • Stimulants (moderate): additive stimulating effects

Adverse Events

  • Headache
  • Irritability
  • Nasal irritation (intranasal)
  • Insomnia if dosed late

Serious Risks

  • Anxiety exacerbation
  • Mania in susceptible individuals

Monitoring (Literature)

  • Cognitive performance
  • Mood stability
  • Sleep quality

Disclaimer

NA-Semax Amidate is not FDA-approved. This content is provided strictly for educational and professional reference purposes. All clinical decisions must be made by a licensed healthcare professional.

Reference Sources